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Beyond Resveratrol®is formulated to help skin damage resulting from exposure to the sun, weather, environment, chemicals, smoking and second hand smoke, toxins, alcohol, poor nutrition and digestive problems. Promising clinical studies have shown that topically applied resveratrol prevented skin cancer. Resveratrol in capsules did not. These studies have demonstrated time and again that topically applied resveratrol is clinically superior to its orally administered counterpart! One jar is the same as doing 1,000's of bottles of dietary supplement resveratrol capsules, or from drinking 1,000 bottles of red wine! This single product can eliminate the need for using one or more expensive over-the-counter skin care products including: moisturizers, eye puffiness creams, wrinkle creams, age-spot creams, skin tightening creams, fine line creams and deep wrinkle creams.
Doctor’s Beyond Resveratrol® cream was formulated by United States patent holder Dr. Mesko to go “beyond” existing skincare products. Our loyal customers and natural doctors consider Doctor’s Beyond Resveratrol® Cream to be the finest skin care product available. Extremely pleased women report that this single product eliminated the need for using one or more expensive over-the-counter skin care products including: moisturizers, eye puffiness creams, wrinkle creams, age-spot creams, skin tightening creams, fine line creams and deep wrinkle creams. Our skin care product is formulated to go “beyond” existing expensive skin care cosmetics and costly over-the-counter skin products to offer skin support to sun damaged, prematurely aged, wrinkled, or malnourished skin on the face, neck and body. It is estimated that 80% of skin damage is caused by the sun.
SUGGESTED USE AND DIRECTIONS: After cleansing and drying the skin, gently message a thin layer of cream on the face, neck, breasts, stomach or other areas of concern first thing in the morning and/or prior to bedtime. If applying in the morning, wait a few minutes after applying and gently wipe excess cream from face and neck. Wait at least 10 minutes to apply cosmetics.
Organic Silica: Organic silicon is an essential element in the regeneration of collagen fibers. Silicon prolilhidroxilasa stimulates the production of an enzyme that is central to the production of abundant collagen fibers leading towards well lubricated joints. Silicon also improves the quality of elastin and is integral in the process which renovates, repairs, and rejuvenates tissue. All connective tissue contains silica, every strand of hair, every inch of skin, every millimetre of nail, every fibre of muscle and portion of bone. Whether they are all strong and healthy depends greatly on how much silica is present. Silica makes hair shine and skin radiant because it holds in moisture. It’s the filler that smoothes out the cracks that appear in our surfaces over time. It holds us together, makes us strong – and our very bones are dependent on it for their structural integrity.
Purified Deionized Water: also known as demineralized water / DM water (DI water, DIW or de-ionized water), is water that has had its mineral ions removed, such as cations like sodium, calcium, iron, copper, anions such as chloride and sulfate.
Organic Magnesium: plays a role in your body's detoxification processes and therefore is important for helping to prevent damage from environmental chemicals, heavy metals and other toxins.
Resveratrol: On January 25, 2009 CBS's 60 Minutes featured a segment on the exciting discovery of a substance called Resveratrol. A polyphenol found in red wine purported to slow down and even reverse the signs of aging. Due to what is known as the 'French Paradox', Resveratrol is highly researched. The French consume very large amounts of animal based saturated fats, yet have an amazing low death rate from coronary artery disease. This 'paradox' is thought to be attributed to the Resveratrol ingested due to the vast amounts of red wine consumed on a daily basis. Clinical tests confirm Resveratrol is also effective at removing excess estrogen from the body. Tests have shown that when applied topically, Resveratrol proved highly effective at slowing down, repairing, and even reversing skin damage caused by sun exposure. Resveratrol has also been documented to directly protect telomeres* to reduce DNA cellular oxidative damage and stress, and offer significant protection against UV-radiation. As we know, aging and disease are caused by cellular mutation. In 2009, the Nobel Prize in Physiology or Medicine was awarded to 3 scientists who discovered human DNA chromosomes are protected by a microscopic region of repetitive DNA at the end of a chromosome called telomeres. This protection helps prevent the end cells from deterioration. Hundreds of additional clinical tests later conducted proved that reducing cellular stress protects these telomeres, thereby slowing the aging process and the onset of disease.*, thereby aiding in the health and protective nature of these vital cellular clusters. The newest clinical research also shows promising results in Resveratrol helping the fight against diabetes. Resveratrol from red wine is retained in the body up to 15 minutes, but in dietary supplement capsules is retained for up to 30 minutes. However, clinical trials have shown that because topically applied Resveratrol is slowly released into the cells through skin absorption, it therefore offers protection for up to 8 hours.
Hyaluronic Acid: The FDA has approved the use of hyaluronic acid during certain eye surgeries including cataract removal, corneal transplantation, and repair of a detached retina and other eye injuries. It is injected into the eye during the procedure to help replace natural fluids. Hyaluronic acid is also used as a lip filler in plastic surgery. Some people apply hyaluronic acid to the skin for healing wounds, burns, skin ulcers, and as a moisturizer. There is also a lot of interest in using hyaluronic acid to prevent the effects of aging. In fact, hyaluronic acid has been promoted as a "fountain of youth."
Superoxide Dismutase Extract (SOD): Superoxide Dismutase (SOD) is an enzyme that repairs cells and reduces the damage done to them by superoxide, the most common free radical in the body. SOD is found in both the dermis and the epidermis, and is key to the production of healthy fibroblasts (skin-building cells). Studies have shown that SOD acts as both an antioxidant and anti-inflammatory in the body, neutralizing the free radicals that can lead to wrinkles and precancerous cell changes. Researchers are currently studying the potential of superoxide dismutase as an anti-aging treatment, since it is now known that SOD levels drop while free radical levels increase as we age.
Collagen: is vital for strengthening blood vessels and giving skin its elasticity and strength. The degradation of collagen causes wrinkles and other skin issues. As a result, collagen is one of the most popular supplements among the elderly - because of its skin healing properties.
Alanine: Alanine is a nonessential amino acid that plays a key role in the glucose-alanine cycle between muscle tissue and the liver. In amino acid-degrading tissues such as muscle, amino groups are pooled as glutamate by transamination reactions. The amino group of glutamate is transferred to pyruvate via alanine aminotransferase, forming alanine and α-ketoglutarate. The alanine is passed into the blood and transported to the liver. This reaction is reversed in the liver where pyruvate can be used in gluconeogenesis to form glucose, which may return to other tissues through the circulatory system.
Histidine: is an essential amino acid important for growth and repair of tissues. It is necessary for the maintenance of myelin sheaths, which protect nerve cells, and the production of red and white blood cells. It is the precursor for histamine, and B-6, niacin, and Vitamin C are necessary for proper metabolism. It is also a precursor for Carnosine and Anserine. Histidine acts as an antioxidant protecting against radiation damage by helping to remove heavy metals from the body. It stimulates the secretion of gastric juices; therefore helping with digestion.
Zinc Oxide USP: is used for the prevention or treatment of minor skin problems, for example cuts, poison ivy, burns and diaper rash. Because the ointment is thick and opaque reflecting and scattering light, it makes an excellent sun block. It is also waterproof, so will stay where it's put on the body during swimming and if a person is sweating.
Acai: Acai contains several substances called anthocyanins and flavonoids. The word anthocyanin comes from two Greek words meaning “plant” and “blue.” Anthocyanins are responsible for the red, purple, and blue hues in many fruits, vegetables, and flowers. Foods that are richest in anthocyanins -- such as blueberries, red grapes, red wine, and acai -- are very strongly colored, ranging from deep purple to black. Anthocyanins and flavonoids are powerful antioxidants that help defend the body against life's stressors. They also play a role in the body's cell protection system. Free radicals are harmful byproducts produced by the body. May interfere with aging and the disease process by neutralizing free radicals.
Rhodiola Rosea: Rhodiola is used for increasing energy, stamina, strength and mental capacity; and as a so-called “adaptogen” to help the body adapt to and resist physical, chemical, environmental stress, strengthening the nervous system and enhancing immunity.
Sweet Almond Oil: Some people apply sweet almond directly to the skin to soften chapped skin, to soothe mucous membranes, and to kill germs.
Olive Oil: A study conducted by Dr. Niva Shapira from Tel Aviv University in Israel and Bob Kuklinski of Rockstock University in Germany found that olive oil, along with other components of a Mediterranean diet, may contribute to the prevention of malignant melanoma. Malignant melanoma, which is the most dangerous type of skin cancer, may be slowed down by consumption of olive oil, which is rich in antioxidants. People have used olive oil for centuries for personal care. It is a great skin moisturizer, in part because it contains linoleic acid, a compound not made by the body, but which prevents water from evaporating. According to Leslie Baumann, M.D., author of The Skin Type Solution, using olives and olive oil can promote healthy skin, as can applying it directly as a moisturizer. Some of the most exciting news, according to Baumann, is that olive oil also contains at least four different antioxidants, which can help "neutralize damaging free radicals that can lead to skin aging and skin cancer." Baumann writes that in studies mice that drank extra virgin olive oil developed less skin cancer after exposure to UV light.
Jojoba Oil: Prior to the 1970’s whale oil was commonly used to keep skin soft, supple and elastic. Since scientists knew jojoba could maintain its texture and not dry even though it was exposed to extreme temperatures for long periods of time, they found a way to cause a wax (oil) to be secreted from the beans of the plant. It was also found that this wax performed better then whale oil on the skin. There was no side effects or toxins found when placed on the skin. Jojoba oil for skin was found to useful for people who have sensitivity due to psoriasis and eczema. In later years it was discovered that those serious acne conditions could treat the acne areas the jojoba oil could clear up the exposed area and leave little to no scarring. Jojoba oil benefits for the skin is that it does not leave an oily sensation or residue like whale oil or other oils applied to the skin. As mentioned earlier, the reason is because instead of oil secreted from the jojoba bean it is a wax. It is a liquid wax applied to the skin and is chemically more closely related to the oil produced from our skin, sebum. Therefore when applied to the skin it penetrates without having a greasy or tacky feeling.Some of the other benefits jojoba oil for the skin is keeping it from dehydrating. Maintaining the skin to be pliant, keeping it elastic, non-comedogenic (retard the production of acne) and has even shown the ability to reduce wrinkles or minimize fine lines.
On January 25, 2009, CBS NEWS cast 60 Minutes featured an in-depth report on the multiple benefits that resveratrol may confer in slowing and even reversing certain aspects of aging. "Scientists have found a substance in red wine that is slowing down the aging process in mice. Will it someday lengthen the lives of humans, too?" Morley Safer reports.
Fountain Of Youth In A Wine Rx?Researchers tell Morley Safer red wine substance resveratrol could one day lengthen lives. "As 60 Minutesreported in January, scientists across the country have identified a substance in red wine called resveratrol that they believe might do more than just protect the heart, but could in very high concentrations significantly extend life by preventing a number of age related illnesses..."If the promise holds true, I think this has the chance to change healthcare," Dr. Christoph Westphal tells correspondent Morley Safer." 5/21/09
The French Paradox The typical French diet is considerably higher in amounts of saturated fats from animal sources than the average American diet. Despite this fact, the French have an amazingly low death rate from coronary heart disease compared to Americans. As consuming high levels of saturated fats from animal sources is associated with increased risks of atherosclerosis and coronary heart disease, this paradox has baffled doctors for over 150 years. It is now believed that this 'paradox' is attributed to the fact that the French wash down their meals with large quantities of red wine containing resveratrol. "Morley Safer found, in 1991, that the French may have lower rates of heart attacks because their diet is high in cheese and wine." 60 Minutes 11/17/91
Resveratrol is proving to be an amazingly beneficial discovery! Clinical studies and tests are currently being conducted on a resveratrol based cure for diabetes!
Live to be 150... Can you do it?
Secrets to Living Longer with Barbara Walters "...I also spoke with two scientists in Boston who say that in the next five years, they plan to have a drug on the market that will treat several of the major diseases of aging. This drug is based on the "good stuff" in red wine called resveratrol." 4/1/08
SECRETS TO LONGER LIFE, Dr. Oz Has the Formula by Diane Sawyer "...first of all, we know there is a chemical called sirtuin that tells the body to live longer...but that same chemical sirtuin could be turned on with other mechanisms. And one of them is one you are going to want to hear about. A lot of folks know that red wine has been purported to be good for you. But it turns out that red wine is red because of a chemical in it called resveratrol. And so, one of the ways we think red wines benefit health is by turning on that same anti-aging chemical. ~ Dr. Mehmet Oz,ABC, Good Morning America 3/23/09
NOW for the FIRST TIME an exciting NEW product that pushes BEYOND the benefits... BEYOND the indications... BEYOND the capsules... BEYOND the industry standard...
Originally prompted by the “French Paradox”, the study of resveratrol is the subject of ongoing worldwide clinical research. The French paradox is the observation that the French suffer a relatively low incidence of coronary heart disease, despite having a diet relatively rich in saturated fats. The phenomenon was first noted by Irish physician Samuel Black in 1819. When a description of this paradox was aired in the United States on 60 Minutes in 1991 with the proposal that red wine decreases the incidence of cardiac diseases, the consumption of red wine increased 44%. In 2002, the average French person consumed 108 grams per day of fat from animal sources while the average American consumed only 72. The French eat four times more butter, 60 percent more cheese and nearly three times more pork. Although the French consume only slightly more total fat, they consume much more saturated fat because Americans consume a much larger proportion of fat in the form of vegetable oil, with most of that being soybean oil. According to data from the British Heart foundation, rates of death in 1999 from coronary heart disease among males aged 35–74 years was 115 per 100,000 people in the U.S. but only 83 per 100,000 in France.
Resveratrol is a phytoalexin (or antibiotic) produced naturally by plants when under attack by pathogens such as bacteria or fungi. It is usually sold as a dietary supplement, but is best known as an element contained in red wine. In grapes, resveratrol is found primarily in the skin and in the seeds. The amount found in grape skins also varies with the type of grape, its geographic origin, and exposure to fungal infection. The amount of fermentation time a wine spends in contact with grape skins is an important determinant of its resveratrol content. In experiments on mice and rats, anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects of resveratrol have been reported.
The groups of Howitz and Sinclair reported in 2003 in the journal Nature that resveratrol significantly extended the lifespan of the yeast Saccharomyces cerevisiae. Later studies conducted by Sinclair showed that resveratrol also prolonged the lifespan of the wormCaenorhabditis elegans and the fruit fly Drosophila melanogaster. In 2006, Italian scientists obtained the first positive result of resveratrol supplementation in a vertebrate. Using a short-lived fish with a median life span of nine weeks, they found that resveratrol increased the median lifespan by 56%. Compared with the control fish at nine weeks, the resveratrol-supplemented fish showed significantly higher general swimming activity and better learning to avoid an unpleasant stimulus.
Sinclair later reported that resveratrol counteracted the detrimental effects of a high-fat diet in mice. The high fat diet (from adding hydrogenated coconut oil to the standard diet), provided 60% of energy from fat, and the mice on it consumed about 30% more calories than the mice on the standard diet. Both the mice fed the standard diet and the high-fat diet plus resveratrol had a 30% lower risk of death than the mice on the high-fat diet. Insulin and glucose levels in mice on the high-fat resveratrol diet were closer to the mice on standard diet than the high-fat mice. Adding resveratrol to the diet of mice inhibit muscle aging and age-related cardiac dysfunction. In 2008, a study found that high doses of resveratrol (a constituent of red wine) mimicked some of the benefits of caloric restriction (including reduced effects of aging) in mice.
The study supported Sinclair's hypothesis that the effects of resveratrol are due to the activation of the Sirtuin 1 gene (or SIRT1). Responsible for cellular regulation, sirtuins regulate important biological pathways. They influence aging, stress resistance, assisting in the repair of DNA, and regulating genes that undergo altered expression with age. In a study of 123 Finnish adults, those born with certain increased variations of the SIRT1 gene had faster metabolisms, helping them to burn energy more efficiently—indicating that the same pathway shown in the lab mice works in humans.
In 1997, it was reported that topical resveratrol applications prevented the development of skin cancer in mice treated with a carcinogen. There have since been dozens of studies of the anti-cancer activity of resveratrol in animal models. The whole body effectiveness of resveratrol is limited by its poor systemic bioavailability. Thus, topical application of resveratrol in mice, both before and after UVB exposure, inhibited the skin damage and decreased skin cancer incidence. However, oral resveratrol was ineffective in treating mice inoculated with melanoma cells. In humans, about 70% of resveratrol given as a pill is absorbed; however, it is rapidly metabolized in the intestines and in the liver. Only trace amounts of resveratrol can be detected in the blood after an oral dose. Resveratrol from wine is even less effective: its highest level in the bloodstream is minimal, and it completely disappears after approximately four hours. As evidenced by the mice experiments, topical application is thought to be the most efficient method of delivery. Resveratrol is thought to work at the metabolic level, stimulating the cells’ anti-aging genes through its genetic, metabolic and biochemical mechanisms.
Resveratrol does provide anti-aging benefits, study shows…….
After some debate, Harvard Medical School researchers are saying they have confirmed that compound resveratrol that's found in red wine does provide anti-aging benefits.
The study, which was published on March 8 in Science, shows that resveratrol stimulates production of SIRT1, a serum that blocks diseases by speeding up the cell's energy production centers known as mitrochondria.
Researchers have also figured out which gene allows resveratrol to produce SIRT1, and believe that some drugs currently in clinical trials may be able to provide the same anti-aging benefits as well.
"In the history of pharmaceuticals, there has never been a drug that binds to a protein to make it run faster in the way that resveratrol activates SIRT1," senior author David Sinclair, Harvard Medical School professor of genetics, said in a press release. "Almost all drugs either slow or block them."
Resveratrol is a naturally-occuring polyphenols antioxidant that is found in some plant products like grapes and cocoa. It is categorized as a phytoalexin, an antimicrobial compound that is produced by plants to protect them from rough environments like excessive ultraviolet light, infections and climate changes.
Resveratrol has been linked to protection against obesity and diabetes, a reduced risk for blood clotting and a way to lower "bad" LDL cholesterol, due to the compound's ability to dilate blood vessels, increase nitric oxide and block the stickiness of platelets. However, some research came into question when Dr. Dipak K. Das, director of the cardiovascular research center at the University of Connecticut who led several reseveratrol studies, was accused of making up results in January 2013.
There was also a controversy behind whether SIRT1's production was actually influenced by resveratrol. Earlier studies have used a man-made chemical group which glowed brighter the more SIRT1 activity went up. Without this chemical, the experiments didn't work. Some scientists believed that because of this, it meant that SIRT1's activity was only a laboratory construct and didn't exist in nature.
"We had six years of work telling us that this was most definitely not an artifact," Sinclair, who initially published a study in 2006 linking resveratrol to SIRT1 and longevity in mice using that man-made chemical, said. "Still, we needed to figure out precisely how resveratrol works. The answer was extremely elegant."
To prove that there was a link between resveratrol and SIRT1, scientists discovered that the man-made chemical was actually close to three amino acids that were naturally found in cells, one of which is tryptophan, the chemical thought to make people drowsy after eating turkey. Instead of using the florescent chemical, researchers used a tryptophan residue in a test tube to see if it would create more SIRT1, which it did.
Then, Sinclair and his team looked at 2,000 mutants of the gene responsible for SIRT1 to find out how resveratrol worked, and found one mutation that stopped resveratrol's effects by swapping out one of the 747 amino acid residues.
After they found where this mutation was found on SIRT1-creating gene and how to control it, researchers replaced the normal SIRT1 gene in manufactured muscle and skin cells with the one that stopped resveratrol's effect. They then introduced resveratrol and some other medications in clinical trials. Resveratrol and some of the medications were able to speed up mitrochondria by activating more SIRT1 in normal cells, but the mutated cells were unaffected by the substances.
"This was the killer experiment," said Sinclair. "There is no rational alternative explanation other than resveratrol directly activates SIRT1 in cells. Now that we know the exact location on SIRT1 where and how resveratrol works, we can engineer even better molecules that more precisely and effectively trigger the effects of resveratrol."
It is important to note that Sinclair is a co-founder and scientific advisor of Sirtris, a GlaxoSmithKline company. Sirtris currently has a number of sirtuin (SIRT1)-activating compounds in clinical trials.
Sinclair told the Telegraph in a separate interview that he wants to continue the studies to see if reveratrol can help people who are already really healthy.
"Things there are also looking promising. We're finding that ageing isn't the irreversible affliction that we thought it was," he commented. "Some of us could live to 150, but we won't get there without more research."
Many agree that the information is promising.
"This is not weak evidence at this point," Leonard Guarente, a biologist at the Massachusetts Institute of Technology and a Sirtris scientific advisory board member, added to the Los Angeles Times. "You would really bet the ranch on this one."
"It might bring together the different views so we can move forward," Brian Kennedy, president and chief executive of the Buck Institute for Research on Aging in Novato, Calif., added in a press release. Kennedy previously questioned the results of studies using resveratrol and yeast. "This is how science works.”
Please Be Advised:
Information contained on this page is for educational purposes only and is not intended to diagnose, treat, cure or prevent any disease. This information has not been evaluated by the Food and Drug Administration (FDA). No claims and no systemic medical claims are made nor implied for the use of this product.
DISCLAIMER: The above information is for educational purposes only and is not intended as a basis for diagnosis, treatment, or to cure any disease. These statements have not been evaluated by the Food and Drug Administration (FDA). This information is not intended to be a substitute for careful medical evaluation and treatment by a competent and licensed health care professional.
DISCLAIMER: Ideas and information contained above are based on years of experience by Dr. Charles Mesko, professional colleagues, and research conducted throughout the world, with extensive review of scientific literature. The above information is for educational purposes only and is not intended as a basis for diagnosis, treatment, or to cure any disease. These statements have not been evaluated by the Food and Drug Administration (FDA). This information is not intended to be a substitute for careful medical evaluation and treatment by a competent and licensed health care professional. Dr. Charles Mesko, Doctor’s Relief, LLC, and/or Fountain of Youth Technologies, Inc., strongly recommend that you do not change any current medications or add any new therapies without personally consulting a fully qualified and licensed health care professional. Dr. Charles Mesko, Doctor’s Relief, LLC, Fountain of Youth Technologies, Inc., employees, staff and associated personnel specifically disclaim any liability arising directly or indirectly from inappropriate use of contained information. This product is not eligible for refunds or return.
SUGGESTED USE AND DIRECTIONS:
After cleansing and drying the skin, gently message a thin layer of cream on the face, neck, breasts, stomach or other areas of concern first thing in the morning and/or prior to bedtime. If applying in the morning, wait a few minutes after applying and gently wipe excess cream from face and neck. Wait at least 10 minutes to apply cosmetics..